A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the develop •Tip progenitors are heterogeneous and follow a gradual process of lineage restriction•Multipotent Krt14+ cells transition into tw

A cellular hierarchy of Notch and Kras signaling controls cell fate specification in the develop •Tip progenitors are heterogeneous and follow a gradual process of lineage restriction•Multipotent Krt14+ cells transition into tw

Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishe •Increased NSC proliferation in NF1-TGD hCOs is RAS-dependent•NF1-TGD have elevated neuronal survival and maturation deficits•In

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